ADALAT XL 30MG EC   (28 TABLETS)

Generic Name: nifedipine
Brand Name: Adalat
Drug class: Calcium channel blocking agents

Adalat and its generic nifedipine is available in strengths of 30mg and 60mg tablets.

Nifedipine belongs to the class of medications called calcium channel blockers, and are used to manage high blood pressure and chest pain (angina). This class of medications helps to control blood pressure by relaxing blood vessels so blood can flow more easily. High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation.

The immediate-acting form of nifedipine is also used to treat coronary spasm, the sudden constriction of the coronary artery in the heart.

Nifedipine works to lower blood pressure by exerting a peripheral vasodilating effect through a direct relaxation of vascular smooth muscle. This response is achieved by the interference of cellular calcium transport within intracellular compartments. The interference in movement of calcium ions into vascular smooth muscle cells and cardiac muscle cells directly affects those muscle cells ability to initiate and maintain a contractile state. As a result, blood vessels stay relaxed allowing for an adequate supply of blood and oxygen to the heart that will lower blood pressure.

Nifedipine must be taken regularly to be effective and should not be used to treat attacks of chest pain when they occur.

Do not take nifedipine if you:

• are allergic to nifedipine or any ingredients of the medication

• are allergic to other drugs that are similar to nifedipine (dihydropyridine calcium antagonists) (e.g., amlodipine, felodipine)

• are breast-feeding

• are or may become pregnant

• have very low blood pressure or are in shock

• are in the period immediately following a heart attack (applies to the immediate-release form of nifedipine)

• have a Kock pouch (ileostomy after a proctocolectomy)

• are taking the medication rifampicin

• have a severe blockage in the digestive system

• have moderate to severe liver disease

• are on any of the following medications:

  • alcohol

  • aldesleukin

  • aliskiren

  • alpha agonists (e.g., clonidine, methyldopa)

  • alpha blockers (e.g., alfuzosin, doxazosin, tamsulosin)

  • amifostine

  • amiodarone

  • amphetamines (e.g., dextroamphetamine, lisdexamphetamine)

  • angiotensin converting enzyme inhibitors (ACEIs; e.g., captopril, lisinopril, ramipril)

  • angiotensin receptor blockers (ARBs; e.g., candasartan, irbesartain, losartan)

  • anti-psychotics (e.g., clozapine, olanzapine, quetiapine, risperidone)

  • aprepitant

  • "azole" antifungals (e.g., itraconazole, ketoconazole, voriconazole)

  • barbiturates (e.g., butalbital, phenobarbital)

  • beta-adrenergic blockers (e.g., atenolol, propranolol, sotalol)

  • bicalutamide

  • bosentan

  • other calcium channel blockers (e.g., amlodipine, diltiazem, verapamil)

  • calcium supplements (e.g., calcium carbonate, calcium citrate)

  • carbamazepine

  • cimetidine

  • clopidogrel

  • cobicistat

  • conivaptan

  • crizotinib

  • cyclosporine

  • dabrafenib

  • dasatinib

  • deferasirox

  • digoxin

  • dipyridamole

  • diuretics (water pills; e.g., aliskiren, amiloride, furosemide, hydrochlorothiazide, triamterene)

  • dronedarone

  • duloxetine

  • enzalutamide

  • grapefruit juice

  • guanfacine

  • haloperidol

  • HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs; e.g., delavirdine, efavirenz, etravirine, nevirapine)

  • HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)

  • hydralazine

  • idelalisib

  • imatinib

  • imipramine

  • ivacaftor

  • levodopa

  • macrolide antibiotics (e.g., clarithromycin, erythromycin)

  • magnesium supplements

  • melatonin

  • methylphenidate

  • mifepristone

  • minoxidil

  • mitotane

  • modafinil

  • monoamine oxidase inhibitors (MAOIs; e.g., moclobemide, phenelzine, rasagiline, selegiline, tranylcypromine)

  • nefazodone

  • nitrates (e.g., nitroglycerin, isosorbide dinitrate, isosorbide mononitrate)

  • obinutuzumab

  • pentoxifylline

  • phenytoin

  • phosphodiesterase 5 inhibitors (e.g., sildenafil, tadalafil, vardenafil)

  • pimozide

  • primidone

  • quinidine

  • quinine

  • rifabutin

  • rifampin

  • rituximab

  • ropinirole

  • sacubitril

  • St. John's wort

  • selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram,  fluoxetine, paroxetine, sertraline)

  • simeprevir

  • stiripentol

  • tacrolimus

  • tizanidine

  • tocilizumab

  • tolcapone

  • vincristine

  • yohimbine

Possible side effects include:

• anxiety

• decreased sexual ability

• dizziness or lightheadedness

• dry mouth

• headache

• leg cramps

• nausea

• nervousness

• trouble sleeping

• unusual tiredness or weakness

• upset stomach

• vomiting

• abdominal cramps

• back pain

• breathing difficulty, coughing, or wheezing

• breast enlargement (men)

• chest tightness

• chest pain (may appear about 30 minutes after medication is taken)

• confusion

• constipation

• diarrhea

• dizziness when rising from a sitting or lying position

• eye pain

• fainting

• increased urination

• irregular or fast, pounding heartbeat

• menstrual changes

• muscle or joint pain

• rash

• signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)

• skin sensitivity to the sun

• symptoms of high blood sugar (e.g., frequent urination, increased thirst, excessive eating, unexplained weight loss, poor wound healing, infections, fruity breath odour)

• swelling of the ankles, feet, or lower legs

• tingling, burning, numbness, or pain in the hands, arms, feet, or legs

© 2023 Arcedpharmas is the registered trademark used under license from YYOUNG Trademark Ltd. All material copyright MediResource Inc. 1996 – 2023. Terms and conditions of use. The contents herein are for informational purposes only. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Source: www.medbroadcast.com/drug/getdrug/Adalat-XL

Disclaimers: The images used on this website are for reference only. The product images shown may represent the range of product, or be for illustration purposes only and may not be an exact representation of the product.

Any returns of a product due to customer dissatisfaction will need to comply with the © 2023 Arcedpharmas Returns Policy.

CRESTOR 40MG BLSPK  (30 TABLETS)

Generic Name: rosuvastatin
Brand Name: Crestor
Drug class: HMG-CoA Reductase Inhibitors, Lipid-Lowering Agents, Statins

WHAT IS THE DOSAGE OF THIS MEDICATION?

Crestor and its generic rosuvastatin is available in the strength of 5 mg, 10 mg, 20 mg, and 40 mg tablets.

WHAT IS THIS MEDICATION USED FOR?

Rosuvastatin belongs to the group of medications known as HMG CoA reductase inhibitors ("statins"). It is used, along with a healthy diet and exercise program, to improve cholesterol levels by decreasing low-density lipoprotein (LDL) cholesterol ('bad cholesterol') and triglycerides in the blood, and increasing high-density lipoprotein (HDL) cholesterol ('good cholesterol') in the blood. It is also used to treat people who have certain inherited cholesterol disorders.

Rosuvastatin works by blocking the enzyme that helps make cholesterol in the body. People with high blood cholesterol levels have a higher risk of heart diseases such as heart attacks. When cholesterol levels are lowered with a combination of medication, diet, and exercise, the risk of heart disease is lowered. It takes 2 to 4 weeks to see the maximum effect of this medication on cholesterol levels in blood tests.

It can also be used to reduce the risk of heart attacks, stroke, and angioplasty for people who have at least 2 risk factors for cardiovascular disease.

Before starting rosuvastatin, you should be following a cholesterol-lowering diet. If appropriate, a program of weight control and physical exercise should also be implemented.

The recommended dose of rosuvastatin ranges between 5 mg and 40 mg once daily. For most people, the usual recommended starting dose of rosuvastatin is 10 mg once daily. If necessary, the dose may be increased to a maximum of 40 mg daily. People who require the maximum dose of 40 mg per day should consult a specialist.

For children 10 to 17 years of age, who have inherited cholesterol disorders, the recommended starting dose is 5 mg taken once daily. Your doctor may increase this dose to a maximum of 10 mg daily, depending on the effectiveness of the medication and how well it is tolerated.

For people with severely reduced liver function, the maximum daily dose is 20 mg.

For people with severely reduced kidney function, the starting dose should be 5 mg daily and the maximum daily dose is 10 mg.

A starting dose of 5 mg daily is recommended for people of Asian descent (Chinese, Filipino, Japanese, Korean, Vietnamese, or Asian-Indian origin) and those who have severe kidney problems. This low dose should also be considered for people who do not need aggressive cholesterol-lowering effects and for people who may be at a greater risk of experiencing muscle-related problems.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

Rosuvastatin may be taken in the morning or in the evening, with or without food.

It is very important that this medication be taken exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and carry on with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children. Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

WHO SHOULD NOT TAKE THIS MEDICATION

Do not take rosuvastatin if you:

• are allergic to rosuvastatin or any ingredients of the medication

• are pregnant

• are breast-feeding

• are taking cyclosporine

• are taking the medications sofosbuvir/velpatasvir/voxilaprevir for chronic hepatitis C virus infection

• have active liver disease or have unexplained increases in certain liver function tests

Do not take the 40 mg strength of rosuvastatin if you:

• are of Asian descent (Chinese, Filipino, Japanese, Korean, Vietnamese, or Asian-Indian origin)

• are taking niacin or a fibrate (e.g., gemfibrozil, fenofibrate)

• have alcoholism or consume large quantities of alcohol

• have an inherited muscle disorder or a family history of these disorders

• have had muscle damage with another statin medication (e.g., lovastatin, pravastatin, simvastatin)

• have hypothyroidism (an underactive thyroid gland)

• have other medical conditions or are taking other medications that would increase blood levels of rosuvastatin (check with your doctor or pharmacist to see if this applies to you)

• have severely reduced liver or kidney function

  ---

POTENTIAL INTERACTION WITH OTHER MEDICATION

The following medications could potentially interact with rosuvastatin:

• antacids (if taken within 2 hours of taking rosuvastatin) (e.g., aluminum hydroxide, calcium carbonate, magnesium hydroxide)

• apalutamide

• bezafibrate

• carbamazepine

• clopidogrel

• cobicistat

• colchicine

• cyclosporine

• dronedarone

• elagolix

• eltrombopag

• eslicarbazepine

• fenofibrate

• gemfibrozil

• hepatitis C antivirals (e.g., glecaprevir and pibrentasvir, grazoprevir, ledipasvir, sofosbuvir, velpatasvir, voxilaprevir)

• HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)

• itraconazole

• letermovir

• niacin (nicotinic acid)

• niacinamide

• pazopanib

• raltegravir

• regorafenib

• repaglinide

• rifampin

• other "statin" anti-cholesterol medications (e.g., atorvastatin, lovastatin, simvastatin)

• teriflunomide

• tolvaptan

• trabectedin

• warfarin

WHAT ARE THE SIDE EFFECTS OF THIS MEDICATION?

Possible side effects include:

• constipation

• decreased sexual ability

• difficulty sleeping

• dizziness

• headache

• nausea

• nightmares

• stomach pain

• breast enlargement

• confusion

• hives

• itching

• numbness, tingling, weakness, or pain in the hands or feet

• persistent cough, with or without shortness of breath

• poor memory

• signs of clotting problems (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don't stop bleeding)

• signs of depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)

• skin rash

• symptoms of high blood sugar (e.g., frequent urination, increased thirst, excessive eating, unexplained weight loss, poor wound healing, infections, fruity breath odour)

• symptoms of liver damage (such as yellow skin or eyes, abdominal pain, dark urine, clay-coloured stools, loss of appetite, nausea and vomiting, or itching)

• symptoms of muscle damage (unexplained muscle pain, tenderness or weakness, or brown or discoloured urine – especially if you also have a fever or a general feeling of being unwell)

• weakness

© 2023 Arcedpharmas is the registered trademark used under license from YYOUNG Trademark Ltd. All material copyright MediResource Inc. 1996 – 2023. Terms and conditions of use. The contents herein are for informational purposes only. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Source: www.medbroadcast.com/drug/getdrug/ACT-Rosuvastatin

Disclaimers: The images used on this website are for reference only. The product images shown may represent the range of product, or be for illustration purposes only and may not be an exact representation of the product.

Any returns of a product due to customer dissatisfaction will need to comply with the © 2023 Arcedpharmas Returns Policy.