CHLORTHALIDONE 50MG (100 TABLETS)

Generic Name: chlorthalidone
Drug class: Thiazide diuretics

WHAT IS THE DOSAGE OF THIS MEDICATION?

Chlorthalidone is available in the strength of 50 mg tablets.

WHAT IS THIS MEDICATION USED FOR?

Chlorthalidone belongs to the group of medications called diuretics (water pill) and is used to treat fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, kidney diseases, or edema caused by taking steroids or estrogen. This medication is also indicated to treat hypertension (high blood pressure). Lowering high blood pressure helps prevent damage to the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure.

Chlorthalidone treats fluid retention and high blood pressure by preventing water absorption from the kidneys through inhibition of the Na+/Cl− symporter in the distal convoluted tubule cells in the kidney. This causes the kidneys to get rid of unneeded water and salt from the body in the urine.

The usual recommended dose of chlorthalidone is 25 mg to 100 mg once daily or in divided doses.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones given here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children. Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

WHO SHOULD NOT TAKE THIS MEDICATION

Do not use chlorthalidone if you:

• are allergic to chlorthalidone, sulfa drugs, thiazide drugs, or any of the ingredients of the medication

• are unable to produce urine

• have severe liver failure

• have severe kidney failure
  

POTENTIAL INTERACTION WITH OTHER MEDICATION

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Inform your doctor about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

The following medications could potentially interact with chlorthalidone:

• alcohol

• aclidinium

• alfuzosin

• allopurinol

• amiodarone

• amphetamines (dextroamphetamine, lisdexamfetamine)

• angiotensin converting enzyme inhibitors (ACEIs; e.g., captopril, lisinopril, ramipril)

• antihistamines (e.g., bilastine, cetirizine, doxylamine, diphenhydramine, hydroxyzine, loratadine)

• antipsychotics (e.g., chlorpromazine, clozapine, haloperidol, olanzapine, quetiapine, risperidone)

• atropine

• barbiturates (e.g., phenobarbital)

• belladonna

• beta 2 agonists (e.g., salbutamol, formoterol, terbutaline)

• benztropine

• brimonidine

• calcium supplements

• carbamazepine

• cholestyramine

• colesevelam

• colestipol

• conivaptan

• corticosteroids (e.g., dexamethasone, prednisone)

• cyclophosphamide

• darifenacin

• desmopressin

• dexmethylphenidate

• diabetes medications diabetes medications (e.g., acarbose, canagliflozin, glyburide, linagliptin, liraglutide, insulin, metformin, rosiglitazone)

• digoxin

• duloxetine

• fesoterodine

• glycopyrrolate

• glycopyrronium

• ipratropium

• ivabradine

• levodopa

• lithium

• methylphenidate

• monoamine oxidase inhibitors (MAOIs; e.g., moclobemide, phenelzine, rasagiline, selegiline, tranylcypromine)

• multivitamins

• muscle relaxants (e.g., cyclobenzaprine, orphenadrine, tizanidine)

• narcotics (e.g., codeine, hydromorphone, morphine, oxycodone)

• nitrates (e.g., isosorbide dinitrate, nitroglycerin)

• nonsteroidal anti-inflammatory medications (NSAIDs; e.g., ibuprofen, naproxen)

• obinutuzumab

• oxcarbazepine

• oxybutynin

• pentoxifylline

• phosphodiesterase 5 inhibitors (e.g., sildenafil, tadalafil, vardenafil)

• quinidine

• riociguat

• ropinirole

• sacubitril

• scopolamine

• selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, fluoxetine, paroxetine, sertraline)

• sodium phosphates

• solifenacin

• tamsulosin

• tiotropium

• tolterodine

• topiramate

• tricyclic antidepressants (e.g., amitriptyline, clomipramine, imipramine)

• umeclidinium

• vitamin D analogs (e.g., calcitriol, cholecalciferol)
  

WHAT ARE THE SIDE EFFECTS OF THIS MEDICATION?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Inform your doctor about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

This is not a complete list of possible side effects. If you notice other effects not listed, please contact your doctor or pharmacist.

Possible side effects include:

• decreased sexual ability

• diarrhea

• dizziness or lightheadedness, especially when getting up from a sitting or lying down position

• headache

• increased sensitivity of skin to sunlight

• loss of appetite

• nausea

• upset stomach

• vertigo (sensation of spinning)

• vomiting

• black, tarry stools

• blood in urine or stools

• cough or hoarseness

• fever or chills

• joint pain

• lower back or side pain

• painful or difficult urination

• pinpoint red spots on skin

• skin rash or hives

• stomach pain (severe) with nausea and vomiting

• unusual bleeding or bruising

• yellow eyes or skin
  

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