COZAAR 50MG 30 TB [MBO]

COZAAR 50MG (30 TABLETS)

Generic Name: losartan
Brand Name: Cozaar
Drug class: Angiotensin receptor blockers

Cozaar and the generic Losartan are available in the strength of 25mg, 50mg, and 100mg tablets.

Losartan belongs to a family of medications known as angiotensin II receptor blockers and are used for the treatment of mild-to-moderate high blood pressure in adults and children over the age of 6, and to protect the kidneys from damage due to Type 2 diabetes.

Angiotensin II is a chemical that the body releases to cause the constriction of blood vessels. Losartan blocks the action of angiotensin II, resulting in the relaxation of the blood vessels. This relaxation causes the blood pressure to drop.

The full effects of losartan are usually seen within 3 to 6 weeks after treatment has started.

The usual recommended dose of losartan for adults is 50 mg or 100 mg once daily. The usual starting dose is 50 mg once daily. In some cases, a lower starting dose of 25 mg once daily may be advisable. Do not take more than 100 mg once daily. Your doctor will adjust the dosage according to individual needs.

The usual recommended dose of losartan for children, aged 6 – 16 years, is based on body weight. The dose is 25 mg once daily for children weighing between 20 kg and 49 kg. This dose may be increased to 50 mg once daily. In children weighing more than 50 kg, the starting dose is 50 mg taken once daily. This dose may be increased to 100 mg once daily.

Losartan may be taken with or without food, but should be taken the same way each day.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important that this medication be taken exactly as prescribed by your doctor. If you miss a dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Do not use losartan if you:

are allergic to losartan or to any of the ingredients of the medication
are pregnant
have diabetes or moderate-to-severe kidney disease and are taking the medication aliskiren
have difficulty urinating or produce no urine

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Inform your doctor about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

are on any of the following medications:
- aldesleukin
- aliskiren
- alpha-agonists (e.g., clonidine, methyldopa)
- alpha-blockers (e.g., alfuzosin, doxazosin, tamsulosin)
- amifostine
- amiodarone
- amphetamines (e.g., dextroamphetamine)
- angiotensin converting enzyme inhibitors (ACEIs; e.g., captopril, lisinopril, ramipril)
- other angiotensin receptor blockers (ARBs; e.g., candesartan, irbesartan)
- antipsychotics (e.g., chlorpromazine, clozapine, haloperidol, olanzapine, quetiapine, risperidone)
- apalutamide
- "azole" antifungals (e.g., itraconazole, ketoconazole, voriconazole)
- barbiturates (e.g., pentobarbital, phenobarbital)
- beta-adrenergic blockers (e.g., atenolol, propranolol, sotalol)
- bosentan
- brimonidine
- calcium channel blockers (e.g., amlodipine, diltiazem, nifedipine, verapamil)
- carbamazepine
- ceritinib
- conivaptan
- cyclosporine
- dabrafenib
- deferasirox
- digoxin
- diabetes medications (e.g., chlorpropamide, glyburide, pioglitazone, repaglinide)
- diuretics (water pills; e.g., furosemide, hydrochlorothiazide, indapamide)
- drospirenone
- duloxetine
- enzalutamide
- eplerenone
- ginger
- ginseng (American)
- guanfacine
- heparin and low-molecular weight heparins (e.g., dalteparin, tinzaparin)
- HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs; e.g., delavirdine, efavirenz, etravirine, nevirapine)
- levodopa
- lithium
- lumacaftor
- methylphenidate
- monoamine oxidase inhibitors (MAOIs; e.g., moclobemide, phenelzine, rasagiline, selegiline, tranylcypromine)
- medications that increase the level of potassium in the blood (e.g., spironolactone, amiloride, triamterene, or salt substitutes that contain potassium)
- mifepristone
- minoxidil
- mitotane
- modafinil
- nitrates (e.g., nitroglycerin, isosorbide dinitrate, isosorbide mononitrate)
- non-steroidal anti-inflammatory medications (NSAIDs; e.g., diclofenac, ibuprofen, naproxen)
- obinutuzumab
- pentoxifylline
- phenytoin
- phosphodiesterase 5 inhibitors (e.g., sildenafil, tadalafil, vardenafil)
- quinine
- rifabutin
- rifampin
- riociguat
- ropinirole
- sacubitril
- St. John's wort
- sarilumab
- sodium phosphates
- tizanidine
- tocilizumab
- tolvaptan
- trimethoprim
- warfarin
- yohimbine

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

This is not a complete list of possible side effects. If you notice other effects not listed, please contact your doctor or pharmacist.

Possible side effects include:

back or leg pain
changed sense of taste
cough
diarrhea
dizziness
fatigue
headache
muscle cramps
vomiting
fainting
heart palpitations (abnormal heartbeat with a feeling of thumping, fluttering, or pounding in the chest)
skin rash - especially if you also have joint pain
signs of clotting problems (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don’t stop bleeding)
signs of kidney problems (e.g., change in the amount or colour of urine, increased urination at night, blood in the urine, swelling in the feet or legs)
signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
signs of too much potassium in the body (e.g., irregular heartbeat, muscle weakness, generally feeling unwell)
unexplained muscle pain, weakness, or dark brown urine

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CRESTOR 40MG BLSPK (30 TABLETS)

Generic Name: rosuvastatin
Brand Name: Crestor
Drug class: HMG-CoA Reductase Inhibitors, Lipid-Lowering Agents, Statins

WHAT IS THE DOSAGE OF THIS MEDICATION?

Crestor and its generic rosuvastatin is available in the strength of 5 mg, 10 mg, 20 mg, and 40 mg tablets.

WHAT IS THIS MEDICATION USED FOR?

Rosuvastatin belongs to the group of medications known as HMG CoA reductase inhibitors ("statins"). It is used, along with a healthy diet and exercise program, to improve cholesterol levels by decreasing low-density lipoprotein (LDL) cholesterol ('bad cholesterol') and triglycerides in the blood, and increasing high-density lipoprotein (HDL) cholesterol ('good cholesterol') in the blood. It is also used to treat people who have certain inherited cholesterol disorders.

Rosuvastatin works by blocking the enzyme that helps make cholesterol in the body. People with high blood cholesterol levels have a higher risk of heart diseases such as heart attacks. When cholesterol levels are lowered with a combination of medication, diet, and exercise, the risk of heart disease is lowered. It takes 2 to 4 weeks to see the maximum effect of this medication on cholesterol levels in blood tests.

It can also be used to reduce the risk of heart attacks, stroke, and angioplasty for people who have at least 2 risk factors for cardiovascular disease.

Before starting rosuvastatin, you should be following a cholesterol-lowering diet. If appropriate, a program of weight control and physical exercise should also be implemented.

The recommended dose of rosuvastatin ranges between 5 mg and 40 mg once daily. For most people, the usual recommended starting dose of rosuvastatin is 10 mg once daily. If necessary, the dose may be increased to a maximum of 40 mg daily. People who require the maximum dose of 40 mg per day should consult a specialist.

For children 10 to 17 years of age, who have inherited cholesterol disorders, the recommended starting dose is 5 mg taken once daily. Your doctor may increase this dose to a maximum of 10 mg daily, depending on the effectiveness of the medication and how well it is tolerated.

For people with severely reduced liver function, the maximum daily dose is 20 mg.

For people with severely reduced kidney function, the starting dose should be 5 mg daily and the maximum daily dose is 10 mg.

A starting dose of 5 mg daily is recommended for people of Asian descent (Chinese, Filipino, Japanese, Korean, Vietnamese, or Asian-Indian origin) and those who have severe kidney problems. This low dose should also be considered for people who do not need aggressive cholesterol-lowering effects and for people who may be at a greater risk of experiencing muscle-related problems.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

Rosuvastatin may be taken in the morning or in the evening, with or without food.

It is very important that this medication be taken exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and carry on with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children. Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

WHO SHOULD NOT TAKE THIS MEDICATION

Do not take rosuvastatin if you:

are allergic to rosuvastatin or any ingredients of the medication
are pregnant
are breast-feeding
are taking cyclosporine
are taking the medications sofosbuvir/velpatasvir/voxilaprevir for chronic hepatitis C virus infection
have active liver disease or have unexplained increases in certain liver function tests

Do not take the 40 mg strength of rosuvastatin if you:

are of Asian descent (Chinese, Filipino, Japanese, Korean, Vietnamese, or Asian-Indian origin)
are taking niacin or a fibrate (e.g., gemfibrozil, fenofibrate)
have alcoholism or consume large quantities of alcohol
have an inherited muscle disorder or a family history of these disorders
have had muscle damage with another statin medication (e.g., lovastatin, pravastatin, simvastatin)
have hypothyroidism (an underactive thyroid gland)
have other medical conditions or are taking other medications that would increase blood levels of rosuvastatin (check with your doctor or pharmacist to see if this applies to you)
have severely reduced liver or kidney function

POTENTIAL INTERACTION WITH OTHER MEDICATION

The following medications could potentially interact with rosuvastatin:

antacids (if taken within 2 hours of taking rosuvastatin) (e.g., aluminum hydroxide, calcium carbonate, magnesium hydroxide)
apalutamide
bezafibrate
carbamazepine
clopidogrel
cobicistat
colchicine
cyclosporine
dronedarone
elagolix
eltrombopag
eslicarbazepine
fenofibrate
gemfibrozil
hepatitis C antivirals (e.g., glecaprevir and pibrentasvir, grazoprevir, ledipasvir, sofosbuvir, velpatasvir, voxilaprevir)
HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
itraconazole
letermovir
niacin (nicotinic acid)
niacinamide
pazopanib
raltegravir
regorafenib
repaglinide
rifampin
other "statin" anti-cholesterol medications (e.g., atorvastatin, lovastatin, simvastatin)
teriflunomide
tolvaptan
trabectedin
warfarin

WHAT ARE THE SIDE EFFECTS OF THIS MEDICATION?

Possible side effects include:

constipation
decreased sexual ability
difficulty sleeping
dizziness
headache
nausea
nightmares
stomach pain
breast enlargement
confusion
hives
itching
numbness, tingling, weakness, or pain in the hands or feet
persistent cough, with or without shortness of breath
poor memory
signs of clotting problems (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don't stop bleeding)
signs of depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)
skin rash
symptoms of high blood sugar (e.g., frequent urination, increased thirst, excessive eating, unexplained weight loss, poor wound healing, infections, fruity breath odour)
symptoms of liver damage (such as yellow skin or eyes, abdominal pain, dark urine, clay-coloured stools, loss of appetite, nausea and vomiting, or itching)
symptoms of muscle damage (unexplained muscle pain, tenderness or weakness, or brown or discoloured urine – especially if you also have a fever or a general feeling of being unwell)
weakness