DIAMICRON MR 30MG  (60 TABLETS)

Generic Name: gliclazide MR
Brand Name: Diamicron MR
Drug Class: Non-sulfonylureas

Diamicron MR and its generic gliclazide MR is available in strengths of: 30 mg and 60 mg tablets.

Gliclazide modified release (MR) belongs to the class of medications called oral hypoglycemics. It is used for the control of blood glucose in people with type 2 diabetes. It is used when diet, exercise, and weight reduction have not been found to control blood glucose well enough without medication. Gliclazide MR increases the amount of insulin released by the pancreas and helps the body use insulin more efficiently.

Gliclazide modified release (MR) works by binding to the β cell sulfonyl urea receptors (SUR1) on the surface of the pancreatic beta-cells. This binding subsequently blocks and closes potassium (K+) ion channels resulting in an intricate cascade that leads to insulin release.

The recommended starting dose of gliclazide MR is 30 mg taken once daily at the same time every day. Your doctor will gradually increase the dose every 2 weeks to a maximum of 120 mg daily, depending on the reduction of your blood glucose. You should take the medication at breakfast time. Do not chew or crush the tablets. The 60 mg tablets can be split in half. The 30 mg tablets cannot be split in half and should be swallowed whole.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, skip the missed dose and take your usual dose at the regular time the next day. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children. Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Do not take gliclazide MR if you:

• are allergic to gliclazide or any ingredients of the medication

• are allergic to other sulfonylureas (such as glyburide) or sulfonamides (such as sulfamethoxazole)

• are pregnant or breast-feeding

• are taking some forms of miconazole (ask your doctor or pharmacist for details)

• are experiencing physical stress such as serious infection, injury, or surgery

• have severe kidney or liver disease

• have type 1 diabetes

• have unstable diabetes or ketoacidosis (a high amount of ketones in your urine)

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