EVRA PATCH (3 PATCHES)

Generic Name: norelgestromin - ethinyl estradiol
Brand Name: Evra
Drug class: Contraceptives

Evra Patch 21 Days (3 Patches per Pack); No generic exists for Evra Patch.

Evra skin patches are used as contraception (birth control) to prevent pregnancy. A form of birth control that is worn on the skin, each patch works by containing a combination of two female hormones (ethinyl estradiol and norelgestromin) that when applied topically utilizes a transdermal system where the medication is continuously absorbed through the skin into the bloodstream. This medication prevents ovulation (the release of an egg from an ovary). Thickens the cervical mucus and uterine lining, making it harder for sperm to reach or harder for a fertilized egg to attach to the uterus.

The Evra patch is to be worn everyday for 3 weeks. During those 3 weeks, the patch is changed (with a new replacing the old) once a week on the same day. During the 4th week, no patch is worn and menstruation will occur. Apply the patch to a different area with each change to avoid skin irritation. Do not allow more than 7 days to pass without a patch on, especially before starting your next 3-week patch cycle as this will increase the likelihood of pregnancy.

Place the Evra patch firmly to a clean, dry section of skin on any of these areas: buttock, abdomen, upper outer arm, or upper torso. Do not apply the patch to skin that is broken or irritated, to the breast, or to an area of skin that may be rubbed by clothing.

Follow the instructions in the package insert or those given to you by your doctor.

A patch is worn every day for 3 weeks. The patch is changed each week and is worn for 7 days. During the 4th week, no patch is worn and menstruation will occur. Always change the patch on the same day of the week. Never be without a patch for longer than 7 days at a time – you may not be protected against pregnancy.

Only one patch should be worn at a time. Apply the patch to clean, dry, healthy skin. It should be applied to the buttock, abdomen, upper outer arm, or upper torso in a spot that will not be rubbed by clothing. Do not apply it to the breast. Do not apply the patch on red, irritated, or cut skin. Do not use creams or other skin products on the area where the patch is currently applied or where you will be soon placing the patch.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones given here, do not change the way you are using the medication without consulting your doctor.

It is important to use this medication exactly as prescribed by your doctor. If you make a dosing error (e.g., forget to change your patch), or if your patch becomes loose or falls off, check the instructions that came with the medication. If you are not sure what to do, contact your doctor and use a backup method of birth control.

Store this medication at room temperature. Each patch should be stored in its protective pouch inside the original box. Keep this medication out of the reach of children. Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Do not use Evra if you:

• are allergic to norelgestromin or ethinyl estradiol or any other ingredients of the medication

• are immobilized for prolonged periods

• are known or suspected to be pregnant

• have or have had blood clots (in the legs, lungs, eyes, or anywhere else) or have severe or multiple risk factors for them

• have or have had a stroke or TIA ("mini-stroke")

• have or have had a heart attack or chest pain (angina)

• have or have had valvular heart disease with complications

• have severe high blood pressure (always >160/100 mmHg)

• have diabetes with blood vessel involvement

• have very high cholesterol

• have health conditions that increase the risk of blood clots (such as certain inherited blood clotting diseases; talk to your doctor for more information)

• smoke and are over the age of 35

• have active liver disease

• have or have had liver tumours (benign or malignant)

• have or are suspected to have breast cancer

• have or are suspected to have cancer of the reproductive organs (e.g., endometrium)

• have undiagnosed abnormal vaginal bleeding

• have yellowing of the skin (jaundice) due to steroids or blocked bile ducts

• have yellowing of the eyes or skin during pregnancy

• have vision problems due to vascular eye disease

• have migraine with focal aura

• have had major surgery associated with an increased risk of blood clots

• are taking the following medication combination used to treat Hepatitis C: paritaprevir, ritonavir, ombitasvir with or without dasabuvir

• are on any of the following medications:

  • anastrozole

  • antibiotics (e.g., ampicillin, metronidazole, penicillin, rifampin, neomycin, tetracyclines)

  • anticonvulsants (e.g., carbamazepine, , phenobarbital, phenytoin, primidone, topiramate, lamotrigine)

  • aprepitant

  • "azole" antifungals (e.g., fluconazole, ketoconazole, voriconazole)

  • barbiturates (e.g., phenobarbital)

  • benzodiazepines (e.g., lorazepam, clonazepam, diazepam)

  • blood pressure medications (e.g., metoprolol, , methyldopa)

  • bosentan

  • celecoxib

  • cholestyramine

  • clozapine

  • cobicistat

  • colesevelam

  • colestipol

  • corticosteroids (e.g., dexamethasone, prednisone)

  • cyclosporine

  • dabigatran

  • diabetes medications (e.g., glyburide, gliclazide, insulin)

  • edoxaban

  • folic acid

  • grapefruit juice

  • heparin

  • Hepatitis C antivirals (e.g., dasabuvir, ombitasvir, paritaprevir, ritonavir)

  • HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs; e.g., efavirenz, etravirine, nevirapine)

  • HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)

  • hyaluronidase

  • levothyroxine

  • low molecular weight heparins (e.g., dalteparin, enoxaparin, tinzaparin)

  • lumacaftor

  • mifepristone

  • modafinil

  • mycophenolate

  • rifabutin

  • rifampin

  • rivaroxaban

  • ropinirole

  • St. John's wort

  • selegiline

  • theophyllines (e.g., aminophylline, oxtriphylline, theophylline)

  • tizanidine

  • tocilizumab

  • tretinoin

  • tranexamic acid

  • tretinoin

  • ursodiol

  • vitamin B12

  • vitamin C (ascorbic acid)

  • warfarin
    

Possible side effects include:

• changes in or painful menstrual periods

• skin irritation, redness, or rash where the patch was applied

• weight gain

• abdominal pain

• acne

• changes in skin pigmentation

• diarrhea

• dizziness

• gas

• gain or loss of body or facial hair

• flu-like illness

• headache (unless it is sudden, severe, or worsening)

• breast pain, tenderness, or swelling

• freckles or darkening of facial skin

• nervousness

• dizziness

• fatigue

• increased hair growth or loss of scalp hair

• mild nausea

• vomiting

• bloating

• stomach cramps

• weight and appetite changes

• problems with contact lenses

• vaginal itching or discharge

• decreased sex drive

© 2023 Arcedpharmas is the registered trademark used under license from YYOUNG Trademark Ltd. All material copyright MediResource Inc. 1996 – 2023. Terms and conditions of use. The contents herein are for informational purposes only. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Source: www.medbroadcast.com/drug/getdrug/Evra

CRESTOR 40MG BLSPK  (30 TABLETS)

Generic Name: rosuvastatin
Brand Name: Crestor
Drug class: HMG-CoA Reductase Inhibitors, Lipid-Lowering Agents, Statins

WHAT IS THE DOSAGE OF THIS MEDICATION?

Crestor and its generic rosuvastatin is available in the strength of 5 mg, 10 mg, 20 mg, and 40 mg tablets.

WHAT IS THIS MEDICATION USED FOR?

Rosuvastatin belongs to the group of medications known as HMG CoA reductase inhibitors ("statins"). It is used, along with a healthy diet and exercise program, to improve cholesterol levels by decreasing low-density lipoprotein (LDL) cholesterol ('bad cholesterol') and triglycerides in the blood, and increasing high-density lipoprotein (HDL) cholesterol ('good cholesterol') in the blood. It is also used to treat people who have certain inherited cholesterol disorders.

Rosuvastatin works by blocking the enzyme that helps make cholesterol in the body. People with high blood cholesterol levels have a higher risk of heart diseases such as heart attacks. When cholesterol levels are lowered with a combination of medication, diet, and exercise, the risk of heart disease is lowered. It takes 2 to 4 weeks to see the maximum effect of this medication on cholesterol levels in blood tests.

It can also be used to reduce the risk of heart attacks, stroke, and angioplasty for people who have at least 2 risk factors for cardiovascular disease.

Before starting rosuvastatin, you should be following a cholesterol-lowering diet. If appropriate, a program of weight control and physical exercise should also be implemented.

The recommended dose of rosuvastatin ranges between 5 mg and 40 mg once daily. For most people, the usual recommended starting dose of rosuvastatin is 10 mg once daily. If necessary, the dose may be increased to a maximum of 40 mg daily. People who require the maximum dose of 40 mg per day should consult a specialist.

For children 10 to 17 years of age, who have inherited cholesterol disorders, the recommended starting dose is 5 mg taken once daily. Your doctor may increase this dose to a maximum of 10 mg daily, depending on the effectiveness of the medication and how well it is tolerated.

For people with severely reduced liver function, the maximum daily dose is 20 mg.

For people with severely reduced kidney function, the starting dose should be 5 mg daily and the maximum daily dose is 10 mg.

A starting dose of 5 mg daily is recommended for people of Asian descent (Chinese, Filipino, Japanese, Korean, Vietnamese, or Asian-Indian origin) and those who have severe kidney problems. This low dose should also be considered for people who do not need aggressive cholesterol-lowering effects and for people who may be at a greater risk of experiencing muscle-related problems.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

Rosuvastatin may be taken in the morning or in the evening, with or without food.

It is very important that this medication be taken exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and carry on with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children. Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

WHO SHOULD NOT TAKE THIS MEDICATION

Do not take rosuvastatin if you:

• are allergic to rosuvastatin or any ingredients of the medication

• are pregnant

• are breast-feeding

• are taking cyclosporine

• are taking the medications sofosbuvir/velpatasvir/voxilaprevir for chronic hepatitis C virus infection

• have active liver disease or have unexplained increases in certain liver function tests

Do not take the 40 mg strength of rosuvastatin if you:

• are of Asian descent (Chinese, Filipino, Japanese, Korean, Vietnamese, or Asian-Indian origin)

• are taking niacin or a fibrate (e.g., gemfibrozil, fenofibrate)

• have alcoholism or consume large quantities of alcohol

• have an inherited muscle disorder or a family history of these disorders

• have had muscle damage with another statin medication (e.g., lovastatin, pravastatin, simvastatin)

• have hypothyroidism (an underactive thyroid gland)

• have other medical conditions or are taking other medications that would increase blood levels of rosuvastatin (check with your doctor or pharmacist to see if this applies to you)

• have severely reduced liver or kidney function

POTENTIAL INTERACTION WITH OTHER MEDICATION

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Inform your doctor about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

The following medications could potentially interact with rosuvastatin:

• antacids (if taken within 2 hours of taking rosuvastatin) (e.g., aluminum hydroxide, calcium carbonate, magnesium hydroxide)

• apalutamide

• bezafibrate

• carbamazepine

• clopidogrel

• cobicistat

• colchicine

• cyclosporine

• dronedarone

• elagolix

• eltrombopag

• eslicarbazepine

• fenofibrate

• gemfibrozil

• hepatitis C antivirals (e.g., glecaprevir and pibrentasvir, grazoprevir, ledipasvir, sofosbuvir, velpatasvir, voxilaprevir)

• HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)

• itraconazole

• letermovir

• niacin (nicotinic acid)

• niacinamide

• pazopanib

• raltegravir

• regorafenib

• repaglinide

• rifampin

• other "statin" anti-cholesterol medications (e.g., atorvastatin, lovastatin, simvastatin)

• teriflunomide

• tolvaptan

• trabectedin

• warfarin

WHAT ARE THE SIDE EFFECTS OF THIS MEDICATION?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Inform your doctor about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

This is not a complete list of possible side effects. If you notice other effects not listed, please contact your doctor or pharmacist.

Possible side effects include:

• constipation

• decreased sexual ability

• difficulty sleeping

• dizziness

• headache

• nausea

• nightmares

• stomach pain

• breast enlargement

• confusion

• hives

• itching

• numbness, tingling, weakness, or pain in the hands or feet

• persistent cough, with or without shortness of breath

• poor memory

• signs of clotting problems (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don't stop bleeding)

• signs of depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)

• skin rash

• symptoms of high blood sugar (e.g., frequent urination, increased thirst, excessive eating, unexplained weight loss, poor wound healing, infections, fruity breath odour)

• symptoms of liver damage (such as yellow skin or eyes, abdominal pain, dark urine, clay-coloured stools, loss of appetite, nausea and vomiting, or itching)

• symptoms of muscle damage (unexplained muscle pain, tenderness or weakness, or brown or discoloured urine – especially if you also have a fever or a general feeling of being unwell)

• weakness

© 2023 Arcedpharmas is the registered trademark used under license from YYOUNG Trademark Ltd. All material copyright MediResource Inc. 1996 – 2023. Terms and conditions of use. The contents herein are for informational purposes only. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Source: www.medbroadcast.com/drug/getdrug/ACT-Rosuvastatin

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