HYDRALAZINE 50MG (100 TABLETS)

Generic Name: hydralazine
Drug class: Vasodilators

Hydralazine is available in the strength of 10 mg, 25 mg, and 50 mg tablets.

Hydralazine belongs to the class of medications called vasodilators and is used to treat high blood pressure. High blood pressure adds to the workload of the heart and arteries. If the additional workload is untreated or left unmanaged, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart or kidney failure.

Hydralazine works to lower blood pressure by exerting a peripheral vasodilating effect through a direct relaxation of vascular smooth muscle. This response is achieved by the interference of cellular calcium transport within intracellular compartments. The interference in movement of calcium ions into vascular smooth muscle cells and cardiac muscle cells directly affects those muscle cells ability to initiate and maintain a contractile state. As a result, blood vessels stay relaxed allowing for an adequate supply of blood and oxygen to the heart that will lower blood pressure.

The dose of hydralazine is based on the individual and depends on the condition being treated and the person's response to the medication. The starting dose of hydralazine tablets is 10 mg taken 4 times a day for the first 2 to 4 days. Depending on how well it is working for you and how well it is tolerated, your doctor will gradually increase the dose. The usual recommended maintenance dose of hydralazine to treat high blood pressure varies from 10 mg to 50 mg 4 times daily. The dose should not be increased over 100 mg per day without further testing by your doctor to determine your acetylator phenotype.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from heat and moisture, and keep it out of the reach of children. Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Do not take hydralazine if you:

• are allergic to hydralazine or any ingredients of the medication

• have an untreated aneurysm in the aorta (large artery leaving the heart)

• have certain heart conditions (e.g., aortic stenosis, mitral stenosis, constrictive pericarditis, cor pulmonale, or a very fast heartbeat combined with heart failure)

• have coronary artery disease

• have lupus (also called systemic lupus erythematosus or SLE)

• have mitral valve rheumatic heart disease

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Inform your doctor about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

• are on any of the following medications:

  • aldesleukin

  • aliskiren

  • alpha-agonists (e.g., clonidine, methyldopa)

  • alpha-blockers (e.g., alfuzosin, doxazosin, tamsulosin)

  • amifostine

  • amiodarone

  • amphetamines (e.g., dextroamphetamine, lisdexamfetamine)

  • angiotensin converting enzyme inhibitors (ACEIs; captopril, enalapril, ramipril)

  • angiotensin receptor blockers (ARBs; e.g., candesartan, irbesartan, losartan)

  • antipsychotics (e.g., aripiprazole. chlorpromazine, lurasidone, paliperidone, quetiapine)

  • barbiturates (e.g., butalbital, pentobarbital, phenobarbital)

  • beta-adrenergic blockers (e.g., atenolol, propranolol, sotalol)

  • brimonidine

  • calcium channel blockers (e.g., amlodipine, diltiazem, nifedipine, verapamil)

  • dexmethylphenidate

  • diuretics (water pills; e.g., furosemide, hydrochlorothiazide, triamterene)

  • duloxetine

  • guanfacine

  • levodopa

  • methylphenidate

  • minoxidil

  • monoamine oxidase inhibitors (MAOIs; e.g., moclobemide, rasagiline, selegiline, tranylcypromine)

  • morphine

  • nitrates (e.g., nitroglycerin, isosorbide dinitrate, isosorbide mononitrate)

  • non-steroidal anti-inflammatory medications (NSAIDs; e.g., diclofenac, ibuprofen, naproxen)

  • obinutuzumab

  • pentoxifylline

  • phosphodiesterase 5 inhibitors (e.g., sildenafil, tadalafil, vardenafil)

  • quinine

  • rotigotine

  • sacubitril

  • sotalol

  • tizanidine

  • tolcapone

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Inform your doctor about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

This is not a complete list of possible side effects. If you notice other effects not listed, please contact your doctor or pharmacist.

Possible side effects include:

• blurred vision

• chest pain

• constipation

• decreased appetite

• diarrhea

• dizziness

• fast heart rate

• fever

• flushing

• headache

• low blood pressure (e.g., fainting, dizziness, lightheadedness, blurred vision, nausea)

• muscle cramps

• nasal congestion

• nausea

• pounding heartbeat

• rash

• stomach upset

• tremor

• fluid retention (e.g., swelling of the feet, ankles, or lower leg)

• increased frequency of infections

• shortness of breath

• signs of anemia (low red blood cells; e.g., dizziness, pale skin, unusual tiredness or weakness, shortness of breath)

• signs of heart problems (e.g., fast, irregular heartbeat or pulse, chest pain, sudden weight gain, difficulty breathing, leg swelling)

• signs of kidney problems (e.g., change in the amount or colour of urine, increased urination at night, blood in the urine, swelling in the feet or legs)

• symptoms of angina (e.g., chest pain, sudden wheeziness, difficulty breathing, or shortness of breath)

• symptoms of liver problems (e.g., nausea, loss of appetite, yellowing of the skin and eyes, abdominal pain, dark urine)

• unexplained joint pain with fever and skin rash

• unusual tiredness

© 2023 Arcedpharmas is the registered trademark used under license from YYOUNG Trademark Ltd. All material copyright MediResource Inc. 1996 – 2023. Terms and conditions of use. The contents herein are for informational purposes only. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Source: www.medbroadcast.com/drug/getdrug/Apo-Hydralazine

Disclaimers: The images used on this website are for reference only. The product images shown may represent the range of product, or be for illustration purposes only and may not be an exact representation of the product.

Any returns of a product due to customer dissatisfaction will need to comply with the © 2023 Arcedpharmas Returns Policy.

CRESTOR 40MG BLSPK  (30 TABLETS)

Generic Name: rosuvastatin
Brand Name: Crestor
Drug class: HMG-CoA Reductase Inhibitors, Lipid-Lowering Agents, Statins

WHAT IS THE DOSAGE OF THIS MEDICATION?

Crestor and its generic rosuvastatin is available in the strength of 5 mg, 10 mg, 20 mg, and 40 mg tablets.

WHAT IS THIS MEDICATION USED FOR?

Rosuvastatin belongs to the group of medications known as HMG CoA reductase inhibitors ("statins"). It is used, along with a healthy diet and exercise program, to improve cholesterol levels by decreasing low-density lipoprotein (LDL) cholesterol ('bad cholesterol') and triglycerides in the blood, and increasing high-density lipoprotein (HDL) cholesterol ('good cholesterol') in the blood. It is also used to treat people who have certain inherited cholesterol disorders.

Rosuvastatin works by blocking the enzyme that helps make cholesterol in the body. People with high blood cholesterol levels have a higher risk of heart diseases such as heart attacks. When cholesterol levels are lowered with a combination of medication, diet, and exercise, the risk of heart disease is lowered. It takes 2 to 4 weeks to see the maximum effect of this medication on cholesterol levels in blood tests.

It can also be used to reduce the risk of heart attacks, stroke, and angioplasty for people who have at least 2 risk factors for cardiovascular disease.

Before starting rosuvastatin, you should be following a cholesterol-lowering diet. If appropriate, a program of weight control and physical exercise should also be implemented.

The recommended dose of rosuvastatin ranges between 5 mg and 40 mg once daily. For most people, the usual recommended starting dose of rosuvastatin is 10 mg once daily. If necessary, the dose may be increased to a maximum of 40 mg daily. People who require the maximum dose of 40 mg per day should consult a specialist.

For children 10 to 17 years of age, who have inherited cholesterol disorders, the recommended starting dose is 5 mg taken once daily. Your doctor may increase this dose to a maximum of 10 mg daily, depending on the effectiveness of the medication and how well it is tolerated.

For people with severely reduced liver function, the maximum daily dose is 20 mg.

For people with severely reduced kidney function, the starting dose should be 5 mg daily and the maximum daily dose is 10 mg.

A starting dose of 5 mg daily is recommended for people of Asian descent (Chinese, Filipino, Japanese, Korean, Vietnamese, or Asian-Indian origin) and those who have severe kidney problems. This low dose should also be considered for people who do not need aggressive cholesterol-lowering effects and for people who may be at a greater risk of experiencing muscle-related problems.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

Rosuvastatin may be taken in the morning or in the evening, with or without food.

It is very important that this medication be taken exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and carry on with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children. Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

WHO SHOULD NOT TAKE THIS MEDICATION

Do not take rosuvastatin if you:

• are allergic to rosuvastatin or any ingredients of the medication

• are pregnant

• are breast-feeding

• are taking cyclosporine

• are taking the medications sofosbuvir/velpatasvir/voxilaprevir for chronic hepatitis C virus infection

• have active liver disease or have unexplained increases in certain liver function tests

Do not take the 40 mg strength of rosuvastatin if you:

• are of Asian descent (Chinese, Filipino, Japanese, Korean, Vietnamese, or Asian-Indian origin)

• are taking niacin or a fibrate (e.g., gemfibrozil, fenofibrate)

• have alcoholism or consume large quantities of alcohol

• have an inherited muscle disorder or a family history of these disorders

• have had muscle damage with another statin medication (e.g., lovastatin, pravastatin, simvastatin)

• have hypothyroidism (an underactive thyroid gland)

• have other medical conditions or are taking other medications that would increase blood levels of rosuvastatin (check with your doctor or pharmacist to see if this applies to you)

• have severely reduced liver or kidney function

  ---

POTENTIAL INTERACTION WITH OTHER MEDICATION

The following medications could potentially interact with rosuvastatin:

• antacids (if taken within 2 hours of taking rosuvastatin) (e.g., aluminum hydroxide, calcium carbonate, magnesium hydroxide)

• apalutamide

• bezafibrate

• carbamazepine

• clopidogrel

• cobicistat

• colchicine

• cyclosporine

• dronedarone

• elagolix

• eltrombopag

• eslicarbazepine

• fenofibrate

• gemfibrozil

• hepatitis C antivirals (e.g., glecaprevir and pibrentasvir, grazoprevir, ledipasvir, sofosbuvir, velpatasvir, voxilaprevir)

• HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)

• itraconazole

• letermovir

• niacin (nicotinic acid)

• niacinamide

• pazopanib

• raltegravir

• regorafenib

• repaglinide

• rifampin

• other "statin" anti-cholesterol medications (e.g., atorvastatin, lovastatin, simvastatin)

• teriflunomide

• tolvaptan

• trabectedin

• warfarin

WHAT ARE THE SIDE EFFECTS OF THIS MEDICATION?

Possible side effects include:

• constipation

• decreased sexual ability

• difficulty sleeping

• dizziness

• headache

• nausea

• nightmares

• stomach pain

• breast enlargement

• confusion

• hives

• itching

• numbness, tingling, weakness, or pain in the hands or feet

• persistent cough, with or without shortness of breath

• poor memory

• signs of clotting problems (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don't stop bleeding)

• signs of depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)

• skin rash

• symptoms of high blood sugar (e.g., frequent urination, increased thirst, excessive eating, unexplained weight loss, poor wound healing, infections, fruity breath odour)

• symptoms of liver damage (such as yellow skin or eyes, abdominal pain, dark urine, clay-coloured stools, loss of appetite, nausea and vomiting, or itching)

• symptoms of muscle damage (unexplained muscle pain, tenderness or weakness, or brown or discoloured urine – especially if you also have a fever or a general feeling of being unwell)

• weakness

© 2023 Arcedpharmas is the registered trademark used under license from YYOUNG Trademark Ltd. All material copyright MediResource Inc. 1996 – 2023. Terms and conditions of use. The contents herein are for informational purposes only. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Source: www.medbroadcast.com/drug/getdrug/ACT-Rosuvastatin

Disclaimers: The images used on this website are for reference only. The product images shown may represent the range of product, or be for illustration purposes only and may not be an exact representation of the product.

Any returns of a product due to customer dissatisfaction will need to comply with the © 2023 Arcedpharmas Returns Policy.