HUMULIN 30/70 CARTRIDGE   (5X3ML)

Generic Name: insulin premixed 30/70
Brand Name: Humulin 30/70
Drug Class: Insulin

Humulin 30/70 is available in two formats:

• 10 mL vial. Each mL contains 100 units of insulin (30 units of regular insulin and 70 units of insulin isophane, human biosynthetic - NPH insulin).

• Penfill Cartridge. Each mL contains 100 units of insulin (30 units of regular insulin and 70 units of insulin isophane, human biosynthetic - NPH insulin).

Insulin is a naturally occurring hormone made by the pancreas that helps our body use or store blood glucose (sugar) it gets from food. For people with diabetes, either the pancreas does not make enough insulin to meet the body's requirements, or the body cannot properly use the insulin that is made. As a result, glucose cannot be used or stored properly and accumulates in the bloodstream. Insulin injected under the skin helps to lower blood glucose levels.

There are many different types of insulin that are absorbed at different rates and work for varying periods of time. This type of premixed insulin contains a mixture of fast-acting insulin (insulin regular) and intermediate-acting insulin (insulin NPH). This premixed insulin is used by people with diabetes who have their blood glucose under control and have found a particular ratio of fast-acting to intermediate-acting insulin that works best for them. This premixed insulin starts working 30 to 60 minutes after injection, has its maximum effect between 2 and 8 hours, and stops working after about 18 to 24 hours.

Your required dose of insulin depends on how much natural insulin your pancreas is producing and how well your body is able to use the insulin. Your doctor or diabetes educator will determine the appropriate dose according to various lifestyle issues and the blood glucose values obtained while monitoring your blood glucose.

Your dose of insulin should be injected subcutaneously (under the skin) to the stomach, upper arm, or thigh regions, exactly as instructed by your doctor or diabetes educator. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas. This will help prevent skin problems from the injections. Do not inject premixed insulin into the vein and do not use premixed insulin in insulin infusion pumps. The dose of insulin is measured in international units (IU). Each mL of insulin contains 100 IU. This premixed insulin is injected about 30 minutes before certain meals. The most common schedule is to use the premixed insulin before breakfast and supper. There are many variations of insulin dosing.

Mix premixed insulin by slowly rolling the bottle or pen between your hands. Premixed insulin suspension should appear cloudy and white. Do not use the insulin if it looks lumpy or grainy, seems unusually thick, sticks to the bottle or vial, or appears discoloured. Do not use the insulin if it contains crystals, if the bottle or vial looks frosted, or if the suspension remains clear after being rolled between your hands.

Keep unopened bottles of insulin in the refrigerator until needed. They may be used until the expiry date on the label. Never allow insulin to freeze. Insulin that is currently in use may be kept at room temperature for no more than 28 days and then discarded. Insulin must not be exposed to extremely hot temperatures or to sunlight. Keep insulin out of the reach of children.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones given here, do not change the way that you are using the medication without consulting your doctor.

It is important to use this medication exactly as prescribed by your doctor. The timing of insulin with respect to your meals is crucial to keeping blood glucose under control and preventing unwanted side effects. Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Do not use Humulin 30/70 if you:

• is allergic to insulin premixed 30/70 or to any of the ingredients of the medication

• has diabetic coma

• has low blood glucose (hypoglycemia)

The following medications could potentially interact with Humulin 30/70:

• ACE inhibitors (e.g., ramipril, enalapril, lisinopril)

• alcohol

• androgens (e.g., testosterone)

• atypical antipsychotics (e.g., clozapine, olanzapine, quetiapine, risperidone)

• beta-blockers (e.g., atenolol, metoprolol, pindolol, propranolol, sotalol)

• birth control pills

• corticosteroids (e.g., prednisone, prednisolone)

• dabrafenib

• danazol

• decongestants (e.g., pseudoephedrine)

• other diabetes medications (e.g., canagliflozin, chlorpropamide, gliclazide, glyburide, metformin, rosiglitazone, sitagliptin)

• disopyramide

• diuretics (e.g., furosemide, hydrochlorothiazide)

• epinephrine

• estrogens (e.g., conjugated estrogen, estradiol, ethinyl estradiol)

• exenatide

• glucagon

• growth hormone

• hepatitis C antivirals (e.g., daclatasvir, dasabuvir, ledipasvir, paritaprevir, ombitasvir, sofosbuvir)

• HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)

• liraglutide

• mifepristone

• monoamine oxidase inhibitors (MAOIs; e.g., moclobemide, phenelzine, rasagiline, selegiline, tranylcypromine)

• niacin

• octreotide

• pasireotide

• pentamidine

• progestins (e.g., dienogest, levonorgestrel, medroxyprogesterone, norethindrone)

• quinine

• quinolone antibiotics (e.g., ciprofloxacin, norfloxacin, ofloxacin)

• salicylates (e.g., ASA)

• selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, fluoxetine, paroxetine, sertraline)

• somatostatin acetate

• sulfa antibiotics (e.g., sulfamethoxazole, sulfadiazine)

• sunitinib

• tacrolimus

• vorinostat

Possible side effects include:

• redness, itching, or swelling at the site of the injection

• signs of low blood glucose:

  • anxiety

  • blurred vision

  • confusion

  • difficulty concentrating

  • difficulty speaking

  • dizziness

  • drowsiness

  • fast heartbeat

  • headache

  • hunger

  • nausea

  • nervousness

  • numbness or tingling of the lips, fingers, or tongue

  • sweating

  • tiredness

  • trembling

  • weakness

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