METOPROLOL-L 25MG 100 TB

METOPROLOL-L 25MG (100 TABLETS)

Generic Name: metroprolol
Brand Name: Lopressor
Drug class: Cardioselective beta blockers

Lopressor and its generic metoprolol is available in the strength of 25 mg, 50 mg, and 100 mg tablets.

Metoprolol belongs to the class of medications called beta-blockers and is used to control cardiovascular diseases, including tachyarrhythmias, high blood pressure, chest pain from not enough blood flow to the heart, and heart failure. High blood pressure adds to the workload of the heart and arteries. If the additional workload is untreated or left unmanaged, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart or kidney failure.

Metoprolol works by blocking a neurotransmitter called catecholamine (adrenaline) from binding to β1-adrenergic receptors, which are mainly found in the heart muscle cells and heart conduction tissue. The union between catecholamine and β1-adrenergic receptors activates greater cardiovascular workload resulting in an increase in blood pressure, heart rate, and oxygen demand. By bisoprolol’s competitive inhibition of β1-adrenergic receptors, the stimuli that is catecholamine is negated from activating greater cardiovascular output. Thus, blood pressure and oxygen demand decreases.

The usual maintenance dose of metoprolol ranges from 100 mg daily to 200 mg daily, however the dose may be increased to 400 mg daily if necessary to obtain symptom control. Immediate-release tablets are taken in 2 divided doses while slow-release tablets are taken once a day.

The medication should be taken with or soon after a meal. Try to take the doses of metoprolol at the same time each day.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important that this medication be taken exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children. Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Do not take metoprolol if you:

are allergic to metoprolol or any ingredients of the medication
are allergic to other beta blockers
are scheduled to have anesthesia with an agent that causes myocardial depression (e.g., ether)
have a condition known as right ventricular failure caused by excessive blood pressure in the lungs
have a condition known as "sick sinus syndrome"
have a slow heartbeat caused by heart rhythm problems
have asthma or other obstructive respiratory diseases (for the intravenous form of metoprolol only)
have an untreated pheochromocytoma (a tumour of the adrenal glands)
have cardiogenic shock
have overt heart failure
have serious heart block
have severe circulatory disorders
have had a heart attack accompanied by:
- a heart rate less than 45 beats per minute
- significant heart block
- very low blood pressure
- moderate to severe cardiac failure

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Inform your doctor about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

are on any of the following medications:
- abiraterone acetate
- acetylcholine
- alcohol
- aldesleukin
- aliskiren
- alpha agonists (e.g., clonidine, methyldopa)
- alpha-1 blockers (e.g., doxazosin, prazosin, tamsulosin)
- amiodarone
- amifostine
- amphetamines (e.g., dextroamphetamine, lisdexamphetamine)
- anesthetic agents
- angiotensin-converting enzyme inhibitors (ACEIs; e.g., captopril, ramipril)
- angiotensin II receptor blockers (ARBs; e.g., irbesartan, losartan)
- antihistamines (e.g., cetirizine, doxylamine, diphenhydramine, hydroxyzine, loratadine, diphenhydramine)
- antimalarials (e.g., chloroquine, hydroxychloroquine, mefloquine, quinine)
- antipsychotics (e.g., chlorpromazine, clozapine, haloperidol, olanzepine, quetiapine, risperidone)
- asunaprevir
- atomoxetine
- azelastine
- barbiturates (e.g., butalbital, pentobarbital, phenobarbital)
- beta-agonists (asthma medications; e.g., salbutamol, salmeterol, formoterol)
- bortezomib
- brimonidine
- buprenorphine
- bupropion
- calcium channel blockers (e.g., verapamil, diltiazem, nifedipine, amlodipine)
- celecoxib
- ceritinib
- cholecalciferol
- cimetidine
- cinacalcet
- clobazam
- clotrimazole
- cobicistat
- cocaine
- cyproterone
- darifenacin
- delavirdine
- dextromethorphan
- digoxin
- diuretics (water pills; e.g., furosemide, hydrochlorothiazide)
- dipyridamole
- disopyramide
- disulfiram
- donepezil
- doxorubicin
- dronedarone
- entacapone
- epinephrine
- ergot derivatives (e.g., bromocriptine, ergotamine, methylergonovine)
- fentanyl
- fingolimod
- flecainide
- floctafenine
- galantamine
- ginger
- ginseng
- grass pollen allergen extract
- guanfacine
- HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
- imatinib
- insulin
- isoniazid
- ketoconazole
- lacosamide
- lanreotide
- levodopa
- lidocaine
- lomustine
- methacholine
- methadone
- methimazole
- methoxsalen
- methylphenidate
- metoclopramide
- midodrine
- mifepristone
- milk thistle
- mirabegron
- moclobemide
- nefazodone
- nevirapine
- nilotinib
- nitrates (e.g., nitroglycerin, isosorbide dinitrate, isosorbide mononitrate)
- nonsteroidal anti-inflammatories (NSAIDs; e.g., ibuprofen, indomethacin, naproxen)
- norepinephrine
- octreotide
- orphenadrine
- other beta-blockers (e.g., atenolol, pindolol, propranolol)
- oxybutynin
- pasireotide
- pazopanib
- peginterferon alfa-2b
- pentoxifylline
- phosphodiesterase-5 inhibitors (e.g., sildenafil, tadalafil)
- pilocarpine
- pimozide
- praziquantel
- propafenone
- proton pump inhibitors (e.g., lansoprazole, omeprazole, rabeprazole)
- quinidine
- quinine
- ranitidine
- regorafenib
- rifabutin
- rifampin
- rituximab
- rivastigmine
- ropinirole
- selective serotonin reuptake inhibitors (e.g., fluoxetine, paroxetine, sertraline)
- serotonin antagonists (anti-emetic medications; e.g., dolasetron, granisetron, ondansetron)
- serotonin/norepinephrine reuptake inhibitors (SNRIs; e.g., desvenlafaxine, duloxetine, venlafaxine)
- sodium phenylbutyrate
- "statin" cholesterol medications (e.g., pravastatin, simvastatin)
- sulfonylureas (e.g., gliclazide, glyburide, tolbutamide)
- temsirolimus
- terbinafine
- theophyllines (e.g., aminophylline, oxtriphylline, theophylline)
- ticagrelor
- ticlopidine
- tizanidine
- tofacitinib
- tolcapone
- tranylcypromine
- tricyclic antidepressants (e.g., amitriptyline, clomipramine, desipramine, trimipramine)
- yohimbine

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

This is not a complete list of possible side effects. If you notice other effects not listed, please contact your doctor or pharmacist.

Possible side effects include:

abdominal pain or discomfort
changes in sexual desire or ability
constipation
diarrhea
dizziness or lightheadedness when rising from a sitting or lying position
dry mouth
fatigue
hair loss
headache
increased sensitivity to sunlight
increased sweating
nausea
trouble sleeping
unusual tiredness or weakness with activity
vivid dreams
vomiting
weight gain
back or joint pain
breathing difficulty or wheezing
changes in hearing
chest pain
cold hands and feet
confusion
flare-up of psoriasis (e.g., pinpoint-sized red spots on skin, red, scaling, or crusted skin)
hallucinations (hearing or seeing things that aren't there)
numbness or tingling sensation in the extremities
signs of clotting problems (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don’t stop bleeding)
signs of depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)
signs of heart problems (e.g., fast, irregular heartbeat or pulse, chest pain, difficulty breathing, tiredness with activity, swelling of feet, ankles, or lower legs)
signs of kidney problems (e.g., increased need to urinate, decreased urine production, skin itching, nausea, vomiting, rash)
signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
slow heartbeat (especially less than 40 beats per minute)
symptoms of low blood pressure (e.g., dizziness, fatigue)
vision changes (e.g., blurred vision, dry eyes, eye pain)

© 2023 Arcedpharmas is the registered trademark used under license from YYOUNG Trademark Ltd. All material copyright MediResource Inc. 1996 – 2023. Terms and conditions of use. The contents herein are for informational purposes only. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Source: www.medbroadcast.com/drug/getdrug/Dom-Metoprolol

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CRESTOR 40MG BLSPK (30 TABLETS)

Generic Name: rosuvastatin
Brand Name: Crestor
Drug class: HMG-CoA Reductase Inhibitors, Lipid-Lowering Agents, Statins

WHAT IS THE DOSAGE OF THIS MEDICATION?

Crestor and its generic rosuvastatin is available in the strength of 5 mg, 10 mg, 20 mg, and 40 mg tablets.

WHAT IS THIS MEDICATION USED FOR?

Rosuvastatin belongs to the group of medications known as HMG CoA reductase inhibitors ("statins"). It is used, along with a healthy diet and exercise program, to improve cholesterol levels by decreasing low-density lipoprotein (LDL) cholesterol ('bad cholesterol') and triglycerides in the blood, and increasing high-density lipoprotein (HDL) cholesterol ('good cholesterol') in the blood. It is also used to treat people who have certain inherited cholesterol disorders.

Rosuvastatin works by blocking the enzyme that helps make cholesterol in the body. People with high blood cholesterol levels have a higher risk of heart diseases such as heart attacks. When cholesterol levels are lowered with a combination of medication, diet, and exercise, the risk of heart disease is lowered. It takes 2 to 4 weeks to see the maximum effect of this medication on cholesterol levels in blood tests.

It can also be used to reduce the risk of heart attacks, stroke, and angioplasty for people who have at least 2 risk factors for cardiovascular disease.

Before starting rosuvastatin, you should be following a cholesterol-lowering diet. If appropriate, a program of weight control and physical exercise should also be implemented.

The recommended dose of rosuvastatin ranges between 5 mg and 40 mg once daily. For most people, the usual recommended starting dose of rosuvastatin is 10 mg once daily. If necessary, the dose may be increased to a maximum of 40 mg daily. People who require the maximum dose of 40 mg per day should consult a specialist.

For children 10 to 17 years of age, who have inherited cholesterol disorders, the recommended starting dose is 5 mg taken once daily. Your doctor may increase this dose to a maximum of 10 mg daily, depending on the effectiveness of the medication and how well it is tolerated.

For people with severely reduced liver function, the maximum daily dose is 20 mg.

For people with severely reduced kidney function, the starting dose should be 5 mg daily and the maximum daily dose is 10 mg.

A starting dose of 5 mg daily is recommended for people of Asian descent (Chinese, Filipino, Japanese, Korean, Vietnamese, or Asian-Indian origin) and those who have severe kidney problems. This low dose should also be considered for people who do not need aggressive cholesterol-lowering effects and for people who may be at a greater risk of experiencing muscle-related problems.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

Rosuvastatin may be taken in the morning or in the evening, with or without food.

It is very important that this medication be taken exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and carry on with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

WHO SHOULD NOT TAKE THIS MEDICATION

Do not take rosuvastatin if you:

are allergic to rosuvastatin or any ingredients of the medication
are pregnant
are breast-feeding
are taking cyclosporine
are taking the medications sofosbuvir/velpatasvir/voxilaprevir for chronic hepatitis C virus infection
have active liver disease or have unexplained increases in certain liver function tests

Do not take the 40 mg strength of rosuvastatin if you:

are of Asian descent (Chinese, Filipino, Japanese, Korean, Vietnamese, or Asian-Indian origin)
are taking niacin or a fibrate (e.g., gemfibrozil, fenofibrate)
have alcoholism or consume large quantities of alcohol
have an inherited muscle disorder or a family history of these disorders
have had muscle damage with another statin medication (e.g., lovastatin, pravastatin, simvastatin)
have hypothyroidism (an underactive thyroid gland)
have other medical conditions or are taking other medications that would increase blood levels of rosuvastatin (check with your doctor or pharmacist to see if this applies to you)
have severely reduced liver or kidney function

POTENTIAL INTERACTION WITH OTHER MEDICATION

The following medications could potentially interact with rosuvastatin:

antacids (if taken within 2 hours of taking rosuvastatin) (e.g., aluminum hydroxide, calcium carbonate, magnesium hydroxide)
apalutamide
bezafibrate
carbamazepine
clopidogrel
cobicistat
colchicine
cyclosporine
dronedarone
elagolix
eltrombopag
eslicarbazepine
fenofibrate
gemfibrozil
hepatitis C antivirals (e.g., glecaprevir and pibrentasvir, grazoprevir, ledipasvir, sofosbuvir, velpatasvir, voxilaprevir)
HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
itraconazole
letermovir
niacin (nicotinic acid)
niacinamide
pazopanib
raltegravir
regorafenib
repaglinide
rifampin
other "statin" anti-cholesterol medications (e.g., atorvastatin, lovastatin, simvastatin)
teriflunomide
tolvaptan
trabectedin
warfarin

WHAT ARE THE SIDE EFFECTS OF THIS MEDICATION?

Possible side effects include:

constipation
decreased sexual ability
difficulty sleeping
dizziness
headache
nausea
nightmares
stomach pain
breast enlargement
confusion
hives
itching
numbness, tingling, weakness, or pain in the hands or feet
persistent cough, with or without shortness of breath
poor memory
signs of clotting problems (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don't stop bleeding)
signs of depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)
skin rash
symptoms of high blood sugar (e.g., frequent urination, increased thirst, excessive eating, unexplained weight loss, poor wound healing, infections, fruity breath odour)
symptoms of liver damage (such as yellow skin or eyes, abdominal pain, dark urine, clay-coloured stools, loss of appetite, nausea and vomiting, or itching)
symptoms of muscle damage (unexplained muscle pain, tenderness or weakness, or brown or discoloured urine – especially if you also have a fever or a general feeling of being unwell)
weakness

© 2023 Arcedpharmas is the registered trademark used under license from YYOUNG Trademark Ltd. All material copyright MediResource Inc. 1996 – 2023. Terms and conditions of use. The contents herein are for informational purposes only. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Source: www.medbroadcast.com/drug/getdrug/ACT-Rosuvastatin