OZEMPIC 0.25MG/0.5MG DOSE 1X2MG PRE-FILLE PEN

Generic Name: semaglutide
Brand Name: Ozempic
Drug Class: Incretin mimetics

WHAT IS THE DOSAGE OF THIS MEDICATION?

Ozempic pre-filled pens is available in doses of

• Ozempic 0.25MG/0.5MG dose 1X2MG pre-filled pen

• Ozempic 1.0MG dose 1X4MG pre-filled pen

WHAT IS THIS MEDICATION USED FOR?

Semaglutide injection is used along with a diet and exercise program to control blood sugar levels in adults with type 2 diabetes (a long term condition in which the body does not produce or use insulin normally and therefore cannot control the amount of sugar in the blood). This medication is used to reduce the risk of major cardiovascular events such as heart disease, stroke, kidney problems, nerve damage, eye problems, loss of limbs, and sexual function associated with people who have type 2 diabetes and uncontrolled high blood sugar levels.

Semaglutide injection works by causing insulin (a hormone produced and secreted by the beta cells of the pancreas that lowers blood sugar levels) release in response to high blood sugar (such as after a meal) and decreasing the amount of sugar your liver makes. That happens because this medication acts as a GLP-1 receptor agonist that selectively binds to and activates the GLP-1 receptor, which increases insulin production when blood sugar is high. Furthermore, this medication inhibits the production and release of sugar by the liver, and reduces food intake by slowing down digestion in the stomach. As a result this assists to control diabetes and weight loss, but it is not a cure.

WHO SHOULD NOT TAKE THIS MEDICATION

Do not use semaglutide if you:

• are allergic to gliclazide or any ingredients of the medication

• are allergic to other sulfonylureas (such as glyburide) or sulfonamides (such as sulfamethoxazole)

• are pregnant or breast-feeding

• are taking some forms of miconazole (ask your doctor or pharmacist for details)

• are experiencing physical stress such as serious infection, injury, or surgery

• have severe kidney or liver disease

• have type 1 diabetes

• have unstable diabetes or ketoacidosis (a high amount of ketones in your urine)

POTENTIAL INTERACTION WITH OTHER MEDICATION

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Inform your doctor about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

The following medications could potentially interact with semaglutide:

• currently on or allergic to insulin or other diabetes medication, such as dulaglutide, exenatide, liraglutide, Byetta, Trulicity, Victoza

WHAT ARE THE SIDE EFFECTS OF THIS MEDICATION?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Inform your doctor about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

This is not a complete list of possible side effects. If you notice other effects not listed, please contact your doctor or pharmacist.

Possible side effects include:

• nausea

• vomiting

• diarrhea

• abdominal pain

• constipation

• heartburn

• burping

• ongoing pain that begins in the upper left or middle of the stomach but may spread to the back, with or without vomiting

• rash; itching; swelling of the eyes, face, mouth, tongue, or throat; or difficulty breathing or swallowing

• decreased urination; or swelling of legs, ankles, or feet

• vision changes

• fainting or dizziness

• pain in upper stomach; yellowing of skin or eyes; fever; or clay-colored stools, rapid heartbeat

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